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商品详细JPT/组蛋白肽H3 23:42 K23ac_R26me2a_K27ac(H3.1t)/SP-His_0604/
JPT/组蛋白肽H3 23:42 K23ac_R26me2a_K27ac(H3.1t)/SP-His_0604/
JPT/组蛋白肽H3 23:42 K23ac_R26me2a_K27ac(H3.1t)/SP-His_0604/
商品编号: SP-His_0604
市场价: ¥3036.00
美元价: 1821.60
产地: 美国(厂家直采)
公司:
产品分类: 其他试剂
公司分类: Other_reagents
联系Q Q: 3392242852
电话号码: 4000-520-616
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商品介绍

Histone Peptide H3 23:42 K23ac_R26me2a_K27ac (H3.1t)

Product Code: SP-His_0604

C-terminally biotinylated synthetic Histone peptide carrying 3 modifications (K23ac, R26me2a, K27ac) derived from human Histone H3, H3.1t (Swiss-Prot Id(s): Q16695).
Amino acid sequence: Ac-Lys(Ac)-VA-Arg(Me2a)-Lys(Ac)-SAPATGGVKKPHRYR-Lys(Biotinoyl)-NH2
Amount: 1 vial containing 10nmol (appr. 35µg)
Purity: >70% (HPLC-MS)
Delivery format: Freeze-dried in amber type glass vials
Application(s): Western Blot, Binding experiments, ELISA, Enzyme kinetics, Pull down assays, Substrate Specifity
Indication(s)/Topic(s): Cancer, Phosphatase,Kinase, Methyltransferase, Acetyltransferase, Histones, Phosphatase, Gene regulation & expression, Epigenetics, Cell signaling, Nucleosome, Aging
Delivery time: 2-5 days

JPT's Histone Code Peptides
As histones are a major focus of epigenetics, JPT's computational scientists compiled a unique library of synthetic posttranslationally modified and unmodified human histone peptides that is now available as individual biotinylated peptides. The peptide library consists of more than seven hundred 20mer peptides from 29 histone families (e.g. H2A[1,19,85...], H2B[1,22,42...], H3[1,23,43...], H4[1,14,44...]). Peptides carry PTMs at reported sites (e.g. acetylation, methylation, phosphorylation, citrullination) in various combinations representing natural variants.
JPT's highly skilled and committed scientific staff ensures that the most appropriate methods and techniques are selected for every synthesis project. All of JPT's catalog peptides are provided with HPLC-MS analyses to confirm the identity and demonstrate the high quality of our peptides.

Benefits of JPT's Histone Code Peptides
- Whole production performed in a regulated European environment according to DIN EN ISO 9001:2015 & GCLP standards; audits welcome!
- For high-throughput screening the whole Histone Code Peptide library is also available displayed on peptide microarrays
- Provision of freeze dried aliquots for enhanced stability
- Proven track record for many applications

Histone Peptide H3 23:42 K23ac_R26me2a_K27ac (H3.1t)

Selected References for Histone Peptide Tools
"Histone H2A and H4 N-Terminal Tails are Positioned by the MEP50 WD-Repeat Protein for Efficient Methylation by the PRMT5 Arginine Methyltransferase"
Burgos et al., J. Biol. Chem. (2015) - PMID: 25713080
"H3K23me2 is a New Heterochromatic Mark in Caenorhabditis elegans"

Vandamme et al.,  Nucleic Acids Res. (2015) - PMID: 26476455
"Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity"
Ho et al. PLOS ONE (2013) - PMID:23451136
"Use of High-Density Histone Peptide Arrays for Parsing the Specificity of a Histone-Modifying Enzyme Complex"
Shechter et al, Application Note (2013) (full text)
"Comprehensive Peptide Microarrays for Histone Research"
Schnatbaum et al, 32th EPS (2012) (full text)

Application Notes
"Use of High-Density Histone Peptide Arrays for Parsing the Specificity of a Histone-Modifying Enzyme Complex"
Shechter et al. Application Note (2013) (full text)
"Comprehensive Characterization of Antibodies Directed towards Epigenetic Histone-Modifications"
Masch et al. Application Note (2015) (full text)

Testimonial for Histone Code Peptide Microarray
"JPT's new extremely high-density histone peptide array is a dramatic leap forward for analysis of the histone code hypothesis. The complete sequence coverage across core histones and histone variants as well as the presence of common and rare histone post-translational modifications "alone and in combination" makes this an unparalleled tool for studying the "writers" and "readers" of the histone code. My laboratory has used these arrays to ask the sequence and PTM dependence of a histone writer enzyme and we have discovered an activity specifying code that will keep us busy for years to come."
David Shechter, PhD, Department of Biochemistry, Albert Einstein College of Medicine, YU (NY, USA)

Histone Peptide H3 23:42 K23ac_R26me2a_K27ac (H3.1t)

Technical Data:
Histone Family Histone H3
Modification 3 Modifications
Sequence Position Tail (1-42)
Isoform H3.1t
Biotinylation Biotinylated Peptide
Application ELISA
Protein Name Histones
Organism Homo sapiens (Human)
Indication / Topic Acetyltransferase
Epigenetics
Kinase
Number of peptides

Further Information:
Amount 1 vial containing 10nmol (appr. 35µg)
Specifications C-terminally biotinylated synthetic Histone peptide carrying 3 modifications (K23ac, R26me2a, K27ac)
Documentation Product Datasheet
Swiss-Prot ID
Q16695
Sequence Ac-Lys(Ac)-VA-Arg(Me2a)-Lys(
Ac)-SAPATGGVKKPHRYR-Lys(Biot
inoyl)-NH2
品牌介绍
JPT的关键技术平台基于该公司强大而长期的技术,化学和生物学背景。JPT已经开发了几种独特的方法,可解决细胞疗法和疫苗开发过程的所有阶段,包括生物标记物发现,新表位优先,免疫监测和疫苗功效测试。此外,这四个技术平台为靶向蛋白质组学和分子诊断奠定了基础。JPT的技术在需要进行肽筛查的领域中得到了广泛的应用。典型示例包括:筛选蛋白肽,酶活性(蛋白酶,激酶,磷酸酶,甲基转移酶)或肽前导结构的系统优化。